Currently, LastDo does not have a native client for Desktop computers. However, it is possible to run LastDo on emulator on most desktop computer systems. An emulator simulates an Android phone within your computer. It can almost do everything that you could do with normal Android phone. My favorite one can installed by installing Android Studio, however, this requires some technical understanding. There are some other ones available that are require less technical knowledge. You could, for example, write notes on LastDo in the emulator on desktop computer, sync and see the notes in your phone.
In recent Android phones, you could choose to show LastDo notifications during "Do Not Disturb" by enabling "Override Do Not Disturb". Go to LastDo app info of Android system settings. Choose notifications. Choose notication category and enable the setting.
If you have a holiday coming and want to skip alarms, do not disable the alarms. "Skip next occurrence" is much better option. Use it many times to skip many days. Your alarms will continue, when your holiday is over.
Notes can be organized very flexibly in LastDo. For example, you could use LastDo as a journal app. In notes tab, you could make a child board named "Journal". The child board could contain cards, which each corresponds to year. Each card could contain child boards with names of months. Then each of these child boards could contain cards, which corresponds to day of a month. Then you could write you journal entries as notes to these cards.
In LastDo Pro, you could setup an alarm to remind you to go to sleep. Instead of alarm ringtone you could make LastDo say through the speaker "Go to Sleep" using read loud setting.
If you are struggling to wake up in the morning, you could setup a challenge alarm with high number of difficulty. You could have a NFC tag somewhere on the other side of your home. You could setup an automation app, such as, Tasker to dismiss your LastDo alarms, when your NFC compatible phone reads the tag using instructions in Automation App Integration.